|
KMID : 0363220120500090810
|
|
Korean Journal of Dermatology
2012 Volume.50 No. 9 p.810 ~ p.813
|
|
|
A Case of Pustular Psoriasis Developed during Infliximab Treatment for Crohn’s Disease
|
|
Kim Jin-Yong
Choi Mi-Ra
Cho Kwang-Hyun
|
|
|
Abstract
|
|
|
|
Infliximab is a monoclonal antibody that binds and inactivates tumor necrosis factor-alpha. It has been successfully used to manage diseases associated with a Th1 profile such as psoriasis, Crohn’s disease, and rheumatoid arthritis. A 15-year-old boy presented for erythematous scaly papules and pustules with crust on his entire body, which had appeared initially 2 months ago. He had been treated with infliximab for Crohn’s disease during the last 14 months and had not been diagnosed with psoriasis. A skin biopsy specimen demonstrated papulosquamous dermatitis with subcorneal pustule formation, suggestive of pustular psoriasis. The patient was treated with oral retinoid 20 mg/d for 3 weeks and 10 mg/d for next 3 weeks with concurrent topical steroid, and most lesions disappeared completely with post inflammatory hyperpigmentation. No evidence of recurrence has been observed during 3 months of followup.
|
|
|
KEYWORD
|
|
|
Infliximab, Pustular psoriasis, TNF-α inhibitor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|